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Renal Physiology, 6th Edition

著者 :
By Bruce M. Koeppen, MD, PhD and Bruce A. Stanton, PhD
Gain a foundational understanding of renal physiology and how the renal system functions in health and disease. Renal Physiology, a volume in the Mosby Physiology Series, explains the fundamentals of this complex subject in a clear and concise manner ...view more

Gain a foundational understanding of renal physiology and how the renal system functions in health and disease. Renal Physiology, a volume in the Mosby Physiology Series, explains the fundamentals of this complex subject in a clear and concise manner, while helping you bridge the gap between normal kidney function and disease with pathophysiology content throughout the book.

ISBNコード :
9780323595681
出版日 :
05-10-2018
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!洋書籍は不課税のため消費税不適用、電子書籍は消費税がご注文決済前に表示・適用されます!

!洋書籍は不課税のため消費税不適用、電子書籍は消費税がご注文決済前に表示・適用されます!

Gain a foundational understanding of renal physiology and how the renal system functions in health and disease. Renal Physiology, a volume in the Mosby Physiology Series, explains the fundamentals of this complex subject in a clear and concise manner, while helping you bridge the gap between normal kidney function and disease with pathophysiology content throughout the book.


特長
  • Helps you easily master the material in a systems-based curriculum with learning objectives, "In the Clinic" and "At the Molecular Level" boxes, chapter summaries, clinical cases with review questions and answers, self-study questions, and a comprehensive exam.
  • Includes more than 250 clear, 2-color diagrams that simplify complex concepts.
  • Features clinical commentaries that show you how to apply what you've learned to real-life clinical situations.
  • Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Complete the Mosby Physiology Series! Systems-based and portable, these titles are ideal for integrated programs.

    • Blaustein, Kao, & Matteson: Cellular Physiology and Neurophysiology
    • Cloutier: Respiratory Physiology
    • Pappano & Wier: Cardiovascular Physiology
    • Johnson: Gastrointestinal Physiology
    • White, Harrison, & Mehlmann: Endocrine and Reproductive Physiology
    • Hudnall: Hematology: A Pathophysiologic Approach

著者情報
By Bruce M. Koeppen, MD, PhD, Dean, Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Connecticut, USA and Bruce A. Stanton, PhD, Andrew C. Vail Professor, Microbiology, Immunology, and Physiology, Director of the Lung Biology Center, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA
詳細情報
ISBN Number 9780323595681
Description Author List By Bruce M. Koeppen, MD, PhD, Dean, Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Connecticut, USA and Bruce A. Stanton, PhD, Andrew C. Vail Professor, Microbiology, Immunology, and Physiology, Director of the Lung Biology Center, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA
Copyright Year 2019
Edition Number 6
Format Book
Trim 191w x 235h (7.50" x 9.25")
Illustrations 91 illustrations (91 in full color)
Imprint Elsevier
Page Count 240
Publication Date 5 Oct 2018
Stock Status IN STOCK

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INTRODUCTION

CHAPTER 1

PHYSIOLOGY OF BODY FLUIDS

Objectives

Concept of Steady-State Balance

Physicochemical Properties of Electrolyte Solutions

Molarity and Equivalence

Osmosis and Osmotic Pressure

Osmolarity and Osmolality

Tonicity

Oncotic Pressure

Specific Gravity

Volumes of Body Fluid Compartments

Composition of Body Fluid Compartments

Fluid Exchange between Body Fluid Compartments

Capillary Fluid Exchange

Cellular Fluid Exchange

Summary

Key Words and Concepts

Self-Study Problems

CHAPTER 2

STRUCTURE AND FUNCTION OF THE KIDNEYS

Objectives

Structure of the Kidneys

Gross Anatomy

Ultrastructure of the Nephron

Ultrastructure of the Glomerulus

Ultrastructure of the Juxtaglomerular Apparatus

Innervation of the Kidneys

Summary

Key Words and Concepts

Self-Study Problems

CHAPTER 3

GLOMERULAR FILTRATION AND RENAL BLOOD FLOW

Objectives

Renal Clearance

Glomerular Filtration Rate

Glomerular Filtration

Determinants of Ultrafiltrate Composition

Dynamics of Ultrafiltration

Renal Blood Flow

Regulation of Renal Blood Flow and Glomerular Filtration Rate

Sympathetic Nerves

Angiotensin II

Prostaglandins

Nitric Oxide

Endothelin

Bradykinin

Adenosine

Natriuretic Peptides

Adenosine Triphosphate

Glucocorticoids

Histamine

Dopamine

Summary

Key Words and Concepts

Self-Study Problems

CHAPTER 4

RENAL TRANSPORT MECHANISMS: NaCl AND WATER ABSORPTION ALONG THE NEPHRON

Objectives

General Principles of Membrane Transport

General Principles of Transepithelial Solute and Water Transport

NaCl, Solute, and Water Reabsorption Along the Nephron

Proximal Tubule

Henle’s Loop

Distal Tubule and Collecting Duct

Regulation of NaCl and Water Reabsorption

Summary

Key Words and Concepts

Self-Study Problems

CHAPTER 5

REGULATION OF BODY FLUID OSMOLALITY: REGULATION OF WATER BALANCE

Objectives

Arginine Vasopressin

Osmotic Control of Arginine Vasopressin Secretion

Hemodynamic Control of Arginine Vasopressin Secretion

Arginine Vasopressin Actions on the Kidneys

Thirst

Renal Mechanisms for Dilution and Concentration of the Urine

Medullary Interstitium

Vasa Recta Function

Assessment of Renal Diluting and Concentrating Ability

Summary

Key Words and Concepts

Self-Study Problems

CHAPTER 6

REGULATION OF EXTRACELLULAR FLUID VOLUME AND NaCl BALANCE

Objectives

Whole-Body Na+ Balance

Concept of Effective Circulating Volume

Volume-Sensing Systems

Volume Sensors in the Low-Pressure Cardiopulmonary Circuit

Volume Sensors in the High-Pressure Arterial Circuit

Volume Sensor Signals

Renal Sympathetic Nerves

Renin-Angiotensin-Aldosterone System

Natriuretic Peptides

Arginine Vasopressin

Control of Renal NaCl Excretion During Euvolemia

Mechanisms for Maintaining Constant Na+ Delivery to the Distal Tubule in Euvolemia

Regulation of Distal Tubule and Collecting Duct Na+ Reabsorption in Euvolemia

Control of Na+ Excretion with Volume Expansion

Control of Na+ Excretion with Volume Contraction

Edema

Alterations in Starling Forces

Capillary Hydrostatic Pressure (Pc)

Plasma Oncotic Pressure (πc)

Lymphatic Obstruction

Capillary Permeability

Role of the Kidneys

Summary

Key Words and Concepts

Self-Study Problems

CHAPTER 7

REGULATION OF POTASSIUM BALANCE

Objectives

Overview of K+ Homeostasis

Regulation of Plasma [K+]

Epinephrine

Insulin

Aldosterone

Alterations of Plasma [K+]

Acid-Base Balance

Plasma Osmolality

Cell Lysis

Exercise

K+ Excretion by the Kidneys

Cellular Mechanisms of K+ Transport by Principal Cells and Intercalated Cells in the Distal Tubule and Collecting Duct

Regulation of K+ Secretion by the Distal Tubule and Collecting Duct

Plasma [K+]

Aldosterone

Arginine Vasopressin

Factors that Perturb K+ Excretion

Flow of Tubular Fluid

Acid-Base Balance

Glucocorticoids

Summary

Key Words and Concepts

Self-Study Problems

CHAPTER 8

REGULATION OF ACID-BASE BALANCE

Objectives

 Buffer System

Overview of Acid-Base Balance

Renal Net Acid Excretion

 Reabsorption Along the Nephron

Regulation of H+ Secretion

Formation of New

Response to Acid-Base Disorders

Extracellular and Intracellular Buffers

Respiratory Compensation

Renal Compensation

Simple Acid-Base Disorders

Metabolic Acidosis

Metabolic Alkalosis

Respiratory Acidosis

Respiratory Alkalosis

Analysis of Acid-Base Disorders

Summary

Key Words and Concepts

Self-Study Problems

CHAPTER 9

REGULATION OF CALCIUM AND PHOSPHATE HOMEOSTASIS

Objectives

Calcium

Overview of Ca++ Homeostasis

Ca++ Transport Along the Nephron

Regulation of Urinary Ca++ Excretion

Calcium-Sensing Receptor

Phosphate

Overview of Pi Homeostasis

Pi Transport Along the Nephron

Regulation of Urinary Pi Excretion

Integrative Review of Parathyroid Hormone and Calcitriol on Ca++ and Pi Homeostasis

Summary

Key Words and Concepts

Self-Study Problems

CHAPTER 10

PHYSIOLOGY OF DIURETIC ACTION

Objectives

General Principles of Diuretic Action

Sites of Action of Diuretics

Response of Other Nephron Segments

Adequate Delivery of Diuretics to Their Site of Action

Volume of the Extracellular Fluid

Diuretic Braking Phenomenon

Mechanisms of Action of Diuretics

Osmotic Diuretics

Carbonic Anhydrase Inhibitors

Loop Diuretics

Thiazide Diuretics

K+-Sparing Diuretics

Aquaretics

Effect of Diuretics on the Excretion of Water and Other Solutes

Solute-Free Water

K+ Excretion

HCO Excretion

Ca++ and Pi Excretion

Summary

Key Words and Concepts

Self-Study Problems

ADDITIONAL READING

A P P E N D I X A INTEGRATIVE CASE STUDIES

A P P E N D I X B NORMAL LABORATORY VALUES

A P P E N D I X C NEPHRON FUNCTION

A P P E N D I X D ANSWERS TO SELF-STUDY PROBLEMS

A P P E N D I X E ANSWERS TO INTEGRATIVE CASE STUDIES

A P P E N D I X F REVIEW EXAMINATION

APPENDIX G ANSWERS TO REVIEW EXAMINATION

INDEX

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