Middleton's Allergy - E-Book, 10th Edition
As both a practical reference for clinicians and researchers and an effective self-assessment tool for board preparation, Middleton's Allergy: Principles and Practice remains the #1 authoritative resource in the field. This fully revised 10th Edition brings you up to date with recent advancements in basic science and clinical applications regarding allergy practice and disease mechanisms, offering unparalleled guidance on the full spectrum of allergy across the lifespan.
ISBNコード :
9780443261701
出版日 :
15-04-2026
As both a practical reference for clinicians and researchers and an effective self-assessment tool for board preparation, Middleton's Allergy: Principles and Practice remains the #1 authoritative resource in the field. This fully revised 10th Edition brings you up to date with recent advancements in basic science and clinical applications regarding allergy practice and disease mechanisms, offering unparalleled guidance on the full spectrum of allergy across the lifespan.
特長
- Uses a concise, logically organized, and consistent chapter structure, with each chapter featuring an opening outline and Summary of Important Concepts box—all designed to make this comprehensive text easily navigable for learning, research, and clinical application
- Contains new content on COVID-19, vaccines, the microbiome, and allergic diseases as related to the effects of climate change, as well as thorough updates throughout the text
- Addresses recent innovations in the diagnosis, prevention, and management of allergic disorders, including emerging global issues, the advent of precision medicine, and new immunologic therapies
- Features 730+ full-color illustrations and offers even more multiple-choice questions online with answers and explanations for effective, efficient self-assessment and study
- Shares the experience and knowledge of a highly renowned editorial board led by Drs. A. Wesley Burks and Robyn E. O’Hehir in coordination with Drs. David H. Broide, Leonard B. Bacharier, Gurjit K. Khurana Hershey, and R. Stokes Peebles, Jr. The 10th Edition expands its international perspective with the addition of two new esteemed editors: Drs. Stephen Durham of UK and Mübeccel Akdis of Switzerland
- Any additional digital ancillary content may publish up to 6 weeks following the publication date
著者情報
Edited by A. Wesley Burks, MD, Dean, UNC School of Medicine; CEO of UNC Health, The University of North Carolina at Chapel Hill, USA; Robyn E. O'Hehir, FRACP, PhD, FRCPath, Alfred Hospital and Monash University, Department of Allergy, Immunology, and Respiratory Medicine, Australia; David H. Broide, Professor of Medicine, University of California San, USA; Leonard B. Bacharier, MD, Vanderbilt University, Doctors' Office Tower, USA; Gurjit K. Khurana Hershey, MD, PhD, Department of Pediatrics, Cincinnati Children’s Hospital, USA; R. Stokes Peebles, Jr., MD, Professor of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Stephen R. Durham, National Heart and Lung Institute, Imperial College, Guy Scadding Building, UK and Mübeccel Akdis, MD, PhD, Swiss Institute of Allergy and Asthma Research, University of Zurich, Switzerland
| ISBN Number | 9780443261701 |
|---|---|
| Description Author List | Edited by A. Wesley Burks, MD, Dean, UNC School of Medicine; CEO of UNC Health, The University of North Carolina at Chapel Hill, USA; Robyn E. O'Hehir, FRACP, PhD, FRCPath, Alfred Hospital and Monash University, Department of Allergy, Immunology, and Respiratory Medicine, Australia; David H. Broide, Professor of Medicine, University of California San, USA; Leonard B. Bacharier, MD, Vanderbilt University, Doctors' Office Tower, USA; Gurjit K. Khurana Hershey, MD, PhD, Department of Pediatrics, Cincinnati Children’s Hospital, USA; R. Stokes Peebles, Jr., MD, Professor of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Stephen R. Durham, National Heart and Lung Institute, Imperial College, Guy Scadding Building, UK and Mübeccel Akdis, MD, PhD, Swiss Institute of Allergy and Asthma Research, University of Zurich, Switzerland |
| Copyright Year | 2027 |
| Edition Number | 10 |
| Format | E-Book |
| Imprint | Elsevier |
| Page Count | 1712 |
| Publication Date | 15 Apr 2026 |
| Stock Status | IN STOCK |
SELF-ASSESSMENT QUESTIONS
Self-assessment questions are included with each chapter
and are available in the eBook. See inside the front cover for
access details.
Contributors
Foreword
Preface
VOLUME 1
SECTION A Basic Sciences Underlying Allergy
and Immunology
1 Innate Immunity
2 Adaptive Immunity
3 Immunoglobulin Structure and Function
4 Immune Tolerance
5 Cytokines in Allergic Inflammation
6 Cellular Adhesion in Inflammation
7 Chemokines
8 The Complement System
9 Lipid Mediators of Hypersensitivity and Inflammation
10 Molecular Biology and Genetic Engineering
11 Biology of Lymphocytes
12 Innate Lymphoid Cells
13 Antigen Presenting Dendritic Cells
14 Biology of Mast Cells and Their Mediators
15 Biology of Basophils
16 Biology of Eosinophils
17 Biology of Neutrophils
18 Biology of Monocytes and Macrophages
19 Airway Epithelial Cells
20 Airway Smooth Muscle in Asthma
21 Pathophysiology of Allergic Inflammation
22 Genetics and Epigenetics in Allergic Diseases
23 Omic and Systems Biology Approaches to Allergic
Disease
24 Immunobiology of IgE and IgE Receptors
25 Neuronal Control of Airway Function in Allergy
SECTION B Aerobiology and Allergens
26 The Structure and Function of Allergens
27 Aerobiology of Outdoor Allergens
28 Indoor Allergens
29 Preparation and Standardization of Allergens and
Allergen Extracts
30 Air Pollution: Indoor and Outdoor
SECTION C The Skin
31 Structure of the Skin and Cutaneous Immunology
32 Atopic Dermatitis
33 Contact Dermatitis
34 Urticaria and Angioedema
35 Hereditary Angioedema and Bradykinin-Mediated
Angioedema
36 Immune Complexes in Disease
SECTION D The Eye
37 Allergic Diseases of the Eye
SECTION E Respiratory Tract
38 The Nose and Control of Nasal Airflow
39 Allergic and Nonallergic Rhinitis
40 Rhinosinusitis and Nasal Polyps
41 Development, Structure, and Physiology in Normal Lung
and in Asthma
42 Respiratory Tract Mucosal Immunology
43 Airway Mucus and the Mucociliary System
44 Epidemiology of Asthma and Allergic Diseases
45 Ontogeny of Immune Development and Its Relationship to
Allergic Diseases and Asthma
46 Climate Change: Allergic Diseases and Asthma
47 Mouse Models of Allergic Airways Disease
48 Diagnosis of Asthma in Infants and Children
49 Management of Asthma in Infants and Children
50 Diagnosis of Asthma in Adults
51 Management of Asthma in Adolescents and Adults
52 Emergency Treatment and Approach to the Patient With
Acute Asthma
53 Approach to the Patient With Exercise-Induced
Bronchoconstriction
54 Asthma and Allergic Diseases During Pregnancy
55 Occupational Allergy and Asthma
56 Pathology of Asthma
57 Allergic Bronchopulmonary Aspergillosis,
Hypersensitivity Pneumonitis, and Epidemic
Thunderstorm Asthma
58 Immunologic Nonasthmatic Diseases of the Lung
59 Approaches to the Patient With Chronic Cough
60 Bronchial and Nasal Challenge Testing
61 Lung Imaging
62 Pharmaceutical Aerosols and Aerosol Drug Delivery
Systems
VOLUME 2
SECTION F Gastrointestinal Tract
63 Gastrointestinal Mucosal Immunology
64 Eosinophilic Gastrointestinal Disorders
SECTION G Systemic Disease
65 Clinical Significance of Immunoglobulin E
66 In Vivo Methods for the Study and Diagnosis of
IgE-Mediated Allergy
67 Approach to the Patient With Recurrent Infections
68 Primary Immunodeficiency Diseases
69 Treatment of Primary Immunodeficiency Diseases
70 HIV Infection and Allergic Disease
71 Laboratory Tests for Allergic and Immunodeficiency
Diseases
72 Eosinophilia and Eosinophil-Related Disorders
73 Mastocytosis
74 Anaphylaxis
75 Insect Allergy
76 Drug Allergy
77 Hypersensitivity to Aspirin and Other Nonsteroidal
Antiinflammatory Drugs
78 Reactions to Foods
79 Oral Food Challenge Testing
80 Food Allergy Management, Prevention, and
Therapy
81 Adverse Reactions to Vaccines
SECTION H Therapeutics
82 Allergen Immunotherapy for Inhalant Allergens
83 Principles of Pharmacotherapeutics
84 Precision Medicine in Allergic Disorders
85 Optimizing Adherence in Practice
86 Anti–Immunoglobulin E Therapy
87 Cytokine-Specific Therapy in Asthma
88 Histamine and Antihistamines
89 Inhaled β2-Agonists
90 Anticholinergic Therapies
91 Glucocorticoids
92 Antileukotriene Therapy in Asthma
93 Unconventional Theories and Unproven Methods in
Allergy
94 Complementary and Integrative Health
Appendix A: CD Molecules
Index
Self-assessment questions are included with each chapter
and are available in the eBook. See inside the front cover for
access details.
Contributors
Foreword
Preface
VOLUME 1
SECTION A Basic Sciences Underlying Allergy
and Immunology
1 Innate Immunity
2 Adaptive Immunity
3 Immunoglobulin Structure and Function
4 Immune Tolerance
5 Cytokines in Allergic Inflammation
6 Cellular Adhesion in Inflammation
7 Chemokines
8 The Complement System
9 Lipid Mediators of Hypersensitivity and Inflammation
10 Molecular Biology and Genetic Engineering
11 Biology of Lymphocytes
12 Innate Lymphoid Cells
13 Antigen Presenting Dendritic Cells
14 Biology of Mast Cells and Their Mediators
15 Biology of Basophils
16 Biology of Eosinophils
17 Biology of Neutrophils
18 Biology of Monocytes and Macrophages
19 Airway Epithelial Cells
20 Airway Smooth Muscle in Asthma
21 Pathophysiology of Allergic Inflammation
22 Genetics and Epigenetics in Allergic Diseases
23 Omic and Systems Biology Approaches to Allergic
Disease
24 Immunobiology of IgE and IgE Receptors
25 Neuronal Control of Airway Function in Allergy
SECTION B Aerobiology and Allergens
26 The Structure and Function of Allergens
27 Aerobiology of Outdoor Allergens
28 Indoor Allergens
29 Preparation and Standardization of Allergens and
Allergen Extracts
30 Air Pollution: Indoor and Outdoor
SECTION C The Skin
31 Structure of the Skin and Cutaneous Immunology
32 Atopic Dermatitis
33 Contact Dermatitis
34 Urticaria and Angioedema
35 Hereditary Angioedema and Bradykinin-Mediated
Angioedema
36 Immune Complexes in Disease
SECTION D The Eye
37 Allergic Diseases of the Eye
SECTION E Respiratory Tract
38 The Nose and Control of Nasal Airflow
39 Allergic and Nonallergic Rhinitis
40 Rhinosinusitis and Nasal Polyps
41 Development, Structure, and Physiology in Normal Lung
and in Asthma
42 Respiratory Tract Mucosal Immunology
43 Airway Mucus and the Mucociliary System
44 Epidemiology of Asthma and Allergic Diseases
45 Ontogeny of Immune Development and Its Relationship to
Allergic Diseases and Asthma
46 Climate Change: Allergic Diseases and Asthma
47 Mouse Models of Allergic Airways Disease
48 Diagnosis of Asthma in Infants and Children
49 Management of Asthma in Infants and Children
50 Diagnosis of Asthma in Adults
51 Management of Asthma in Adolescents and Adults
52 Emergency Treatment and Approach to the Patient With
Acute Asthma
53 Approach to the Patient With Exercise-Induced
Bronchoconstriction
54 Asthma and Allergic Diseases During Pregnancy
55 Occupational Allergy and Asthma
56 Pathology of Asthma
57 Allergic Bronchopulmonary Aspergillosis,
Hypersensitivity Pneumonitis, and Epidemic
Thunderstorm Asthma
58 Immunologic Nonasthmatic Diseases of the Lung
59 Approaches to the Patient With Chronic Cough
60 Bronchial and Nasal Challenge Testing
61 Lung Imaging
62 Pharmaceutical Aerosols and Aerosol Drug Delivery
Systems
VOLUME 2
SECTION F Gastrointestinal Tract
63 Gastrointestinal Mucosal Immunology
64 Eosinophilic Gastrointestinal Disorders
SECTION G Systemic Disease
65 Clinical Significance of Immunoglobulin E
66 In Vivo Methods for the Study and Diagnosis of
IgE-Mediated Allergy
67 Approach to the Patient With Recurrent Infections
68 Primary Immunodeficiency Diseases
69 Treatment of Primary Immunodeficiency Diseases
70 HIV Infection and Allergic Disease
71 Laboratory Tests for Allergic and Immunodeficiency
Diseases
72 Eosinophilia and Eosinophil-Related Disorders
73 Mastocytosis
74 Anaphylaxis
75 Insect Allergy
76 Drug Allergy
77 Hypersensitivity to Aspirin and Other Nonsteroidal
Antiinflammatory Drugs
78 Reactions to Foods
79 Oral Food Challenge Testing
80 Food Allergy Management, Prevention, and
Therapy
81 Adverse Reactions to Vaccines
SECTION H Therapeutics
82 Allergen Immunotherapy for Inhalant Allergens
83 Principles of Pharmacotherapeutics
84 Precision Medicine in Allergic Disorders
85 Optimizing Adherence in Practice
86 Anti–Immunoglobulin E Therapy
87 Cytokine-Specific Therapy in Asthma
88 Histamine and Antihistamines
89 Inhaled β2-Agonists
90 Anticholinergic Therapies
91 Glucocorticoids
92 Antileukotriene Therapy in Asthma
93 Unconventional Theories and Unproven Methods in
Allergy
94 Complementary and Integrative Health
Appendix A: CD Molecules
Index
Review of the previous edition:
"Since its inception, this two-volume book has served as a comprehensive resource for allergists, specifically fellows-in-training.The present edition continues the reputation of the original, enjoying contributions from over 200 experts in the field." --Massoud Mahmoudi, DO, PhD (University of California San Francisco) Doodys Review Service
"Since its inception, this two-volume book has served as a comprehensive resource for allergists, specifically fellows-in-training.The present edition continues the reputation of the original, enjoying contributions from over 200 experts in the field." --Massoud Mahmoudi, DO, PhD (University of California San Francisco) Doodys Review Service
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